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KMID : 0377619700190050385
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Korean Jungang Medical Journal
1970 Volume.19 No. 5 p.385 ~ p.391
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Histopathologic Evaluation of Testicular Biopsies in Azoospermias among Koreans
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金智煥/Kim, C.W
韓雲燮/徐相烈/曺湘昊/崔弘悅/李有福/Han, W.S/Suh, S.Y/Cho, S.H/Choi, H.Y/Lee, Y.B
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Abstract
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It is well known fact that testicular biopsy is very important and valuable in diagnosisi therapy and prognosis of male fertility. Charny, in 1940, reported on the use of the testicular biopsy at first in human male sterility, and since then extensive studies were performed by Engle (1947), Nelson (1953), and Girgis et al (1969).
According to the changes of the seminiferous tubules they classified the microscopic findings of the testis into four major patterns, such as normal spermatogenesis, germinal aplasia, spermatogenic arrest (or germinal cell arrest) and progressive tubular fibrosis. Thus accurate causative diagnosis of the azoospermia is a great value for the treatment. Unfortunately no analytical studies for the cause of azoospermia among Koreans have been made up to now. Materials for -this analysis consist of azoospermic patients from January, 1961 to September, 1969 at Severance Hospital of Yonsei university.
Biopsy was taken for the diagnosis of male sterility after the semen analysis proved azoospermia. Routine hematoxylin-eofiin stain was used for histologic studies.
The age of these patients ranged between 20 and 59 years, being most patients between 30 and 39 years. Among 96 patients, 46(48,%) showed various degree of spermatogenesis while 50 patients (52%), were non -spermatogenic, suggesting non-obstructive features. Patients with spermatogenesis were divided into normal activity and mild to marked decrease. of spermatogenesis.
Normal spermatogenesis was found in 23 patients (50% of these patients), mild decreased spermatogenesis in 15 patients (32.6%), and 8 patients (17.4%) showed marked decrease of spermatogenesis.
Leydig cells in the patients with spermatogenic activity were seen in small patches showing normal pattern or mild increase in some cases.
Interstitial fibrosis progressed as the spermatogenesis decreases but distinctive difference was not observed.
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